L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE
CAS: 31828-68-9
Molecular Formula: C4H8ClNOS
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE - Names and Identifiers
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C4H8ClNOS |
| Molar Mass | 153.63 |
| Melting Point | 185-191°C |
| Solubility | Aqueous Acid (Slightly), DMSO (Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | Pale Beige |
| BRN | 3911455 |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| In vitro study | In all cell types, from bacterial to human, homocysteine is metabolized to homocysteine thiolactone by methionyl-tRNA synthetase. Elevated levels of homocysteine are an independent risk factor for cardiovascular disease in humans. Homocysteine can be harmful to human cells because of its metabolic conversion to homocysteine thiolactone, a reactive thioester. This conversion occurs in all human cell types, including endothelial cells. Homocysteine thiolactone induces cell death and features of apoptosis including increased phosphotidylserine exposure on the membrane surface, increased apoptotic cells with hypoploid DNA contents, and internucleosomal DNA fragmentation in HL-60 cells. Homocysteine thiolactone is cytotoxic and capable of promoting cell death, as measured by caspase-3 activation and DNA fragmentation. HcyT strongly activates IL-8 release. |
| In vivo study | Homocysteine thiolactone is toxic, induces epileptic seizures in rodents, and has been implicated in Alzheimer’s disease. Homocysteine thiolactone induces two types of seizures, the coexistence of convulsive and nonconvulsive epilepsy. The grade of seizures is dose dependent. |
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 1-8-9 |
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 6.509 ml | 32.546 ml | 65.091 ml |
| 5 mM | 1.302 ml | 6.509 ml | 13.018 ml |
| 10 mM | 0.651 ml | 3.255 ml | 6.509 ml |
| 5 mM | 0.13 ml | 0.651 ml | 1.302 ml |
Last Update：2024-01-02 23:10:35
L-HOMOCYSTEINE THIOLACTONE HYDROCHLORIDE - Reference Information
| biological activity | L-Homocysteine thiolactone hydrochloride are intramolecular thioesters of homocysteine; prevent homocysteine from being converted into protein. |
| in vitro study | in all cell types, from bacterial to human, homocysteine is metabolized to homocysteine thiolactone by methionyl-tRNA synthetase. Elevated levels of homocysteine are an independent risk factor for cardiovascular disease in humans. Homocysteine can be harmful to human cells because of its metabolic conversion to homocysteine thiolactone, A reactive thioester. This conversion in all human cell types, including endothelial cells. Homocysteine thiolactone induces cell death and features of apoptosis including increased phosphotidylserine exposure on the membrane surface, increased apoptotic cells with hypoploid DNA contents, and internucleosomal DNA fragmentation in HL-60 cells. Homocysteine thiolactone is cytotoxic and capable of promoting cell death, as measured by caspase-3 activation and DNA fragmentation. HcyT strongly activates IL-8 release. |
| in vivo research | Homocysteine thiolactone is toxic, induces epileptic seizures in rodents, and has been implicated in Alzheimer's disease. Homocysteine thiolactone induces two types of seizures, the coexistence of convulsive and nonconvulsive epilepsy. The grade of seizures is dose dependent. |
Last Update：2024-04-10 22:29:15
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